Wednesday, October 11, 2023

Cetirizine (Anti-allergic) Antihistamine Uses, MOA, Dosage, Side effects and ADRs

What is Cetirizine?

Cetirizine is a second generation antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Cetirizine is also used to treat an allergic reaction, itching and swelling caused by chronic urticaria (hives) and minimizes or eliminates the symptoms of perennial allergic rhinitis, seasonal allergic rhinitis, chronic idiopathic urticaria, allergic asthma, physical urticaria, and atopic dermatitis.


‼️ Warnings ‼️ 

Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of cetirizine.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, and then feeling drowsy.

What should I avoid?

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine.

Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It can increase some of the side effects of cetirizine.

Cetirizine acute and common side effects:

Get emergency medical help if you have any serious adverse effects or any of these signs of an allergic reaction: chronic idiopathic urticaria (hives); difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using cetirizine and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;

  • weakness, tremors (uncontrolled shaking), or sleep problems (insomnia);

  • severe restless feeling, hyperactivity;

  • confusion;

  • problems with vision; or

  • urinating less than usual or not at all.

Less serious cetirizine side effects may include:

  • dizziness, drowsiness;

  • tired feeling;

  • dry mouth;

  • sore throat, cough;

  • nausea, constipation; or

  • headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Cetirizine Dosage

πŸ‘‰πŸ»Applies to the following strengths: 10 mg; 5 mg; 1 mg/mL; 2.5 mg; 10 mg/mL

Usual Adult Dose for Allergic Rhinitis

5 to 10 mg orally once a day

  • Maximum dose: 10 mg/day

Uses:

  • Relief of symptoms associated with perennial allergic rhinitis due to allergens (e.g., sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, tearing)
  • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Usual Adult Dose for Urticaria

5 to 10 mg orally once a day

  • Maximum dose: 10 mg/day

Uses:

  • Relief of symptoms associated with perennial allergic rhinitis due to allergens (e.g., sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, tearing)
  • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Usual Geriatric Dose for Allergic Rhinitis

5 to 10 mg orally once a day

  • Maximum dose: 10 mg/day
Comment:
  • Some experts recommend: Patients over 65 years of age should start with 5 mg orally once a day.
Uses:
  • Relief of symptoms associated with perennial allergic rhinitis due to allergens (e.g., sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, tearing)
  • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Usual Pediatric Dose for Allergic Rhinitis

6 months to 2 years:

  • Initial dose: 2.5 mg orally once a day
  • Maintenance dose: 2.5 mg orally once to 2 times a day
  • Maximum dose: 5 mg/day
2 to 5 years:
  • Initial dose: 2.5 mg orally once a day
  • Maintenance dose: 2.5 mg orally 2 times a day OR 5 mg orally once a day
  • Maximum dose: 5 mg/day
6 years and older: 5 to 10 mg orally once a day
  • Maximum dose: 10 mg/day
Uses:
  • Relief of symptoms associated with perennial allergic rhinitis due to allergens (e.g., sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, tearing) in patients 2 years and older
  • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months and older

Usual Pediatric Dose for Urticaria

6 months to 2 years:

  • Initial dose: 2.5 mg orally once a day
  • Maintenance dose: 2.5 mg orally once to 2 times a day
  • Maximum dose: 5 mg/day
2 to 5 years:
  • Initial dose: 2.5 mg orally once a day
  • Maintenance dose: 2.5 mg orally 2 times a day OR 5 mg orally once a day
  • Maximum dose: 5 mg/day
6 years and older: 5 to 10 mg orally once a day
  • Maximum dose: 10 mg/day
Uses:
  • Relief of symptoms associated with perennial allergic rhinitis due to allergens (e.g., sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, tearing) in patients 2 years and older
  • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months and older

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